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The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B <t>),</t> <t>OCI-AML3</t> ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated
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The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B ), OCI-AML3 ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated

Journal: Journal of Experimental & Clinical Cancer Research : CR

Article Title: RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia

doi: 10.1186/s13046-026-03657-y

Figure Lengend Snippet: The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B ), OCI-AML3 ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated

Article Snippet: Kasumi-1, THP-1, MV4-11, and U937 AML cells were purchased from ATCC (Manassas, VA), and MOLM-13, MOLM-14, OCI-AML3, and OCI-AML2 cells were obtained from DSMZ (Braunschweig, Germany).

Techniques: Activity Assay, Expressing, Staining, Flow Cytometry

RGX-019-MMAE in combination with venetoclax enhanced AML cell killing. A , B Bar graphs show the absolute count of live leukemic cells in OCI-AML3 ( A ) and THP-1 ( B ) cell lines treated with indicated concentrations of venetoclax, RGX-019, and/or RGX-019-MMAE. Flow cytometry was used to determine the combinatorial effects of RGX-019-MMAE or monoclonal antibody RGX-019 with venetoclax. Annexin V-FITC was used as an apoptosis marker, and cell viability was determined with DAPI. (Welch one-way ANOVA) * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001

Journal: Journal of Experimental & Clinical Cancer Research : CR

Article Title: RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia

doi: 10.1186/s13046-026-03657-y

Figure Lengend Snippet: RGX-019-MMAE in combination with venetoclax enhanced AML cell killing. A , B Bar graphs show the absolute count of live leukemic cells in OCI-AML3 ( A ) and THP-1 ( B ) cell lines treated with indicated concentrations of venetoclax, RGX-019, and/or RGX-019-MMAE. Flow cytometry was used to determine the combinatorial effects of RGX-019-MMAE or monoclonal antibody RGX-019 with venetoclax. Annexin V-FITC was used as an apoptosis marker, and cell viability was determined with DAPI. (Welch one-way ANOVA) * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001

Article Snippet: Kasumi-1, THP-1, MV4-11, and U937 AML cells were purchased from ATCC (Manassas, VA), and MOLM-13, MOLM-14, OCI-AML3, and OCI-AML2 cells were obtained from DSMZ (Braunschweig, Germany).

Techniques: Flow Cytometry, Marker